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Pathology & Laboratory Medicine
The Pathology & Laboratory Medicine team helps diagnose, treat, and monitor illnesses by studying the body's blood, fluids, tissues, and other samples. Accurate diagnoses for any condition depend on the level of expertise of pathologists and clinical laboratory scientists. By offering advanced laboratory services onsite, we're able to administer specialized diagnostic tests and promptly provide detailed information about your child's condition. Since 70% of all healthcare decisions are based on lab results, it is crucial to have confidence in the lab you choose for your children. You can trust the experience and skill of our board-certified pathologists and clinical laboratory scientists. We specialize in children, babies, and teens so you can be confident that our team will work with you to meet the special needs of your child. |
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Find Us
Main Hospital
747 52nd Street
Oakland, CA 94609
Phone: Clinical Lab (510) 428-3525 | Pathology (510) 428-3530
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Anatomic Pathology Services
Pathology is the study of the nature of disease. The Anatomic Pathology Laboratory provides a full range of pediatric pathology diagnostic services including pediatric surgical pathology, pediatric autopsy, and pediatric cytopathology. Pathologists at Children's Hospital are both investigative researchers looking for the origins of disease and integral members of the patient care team consulting with physicians on biochemical, molecular, and cell biology tests that guide diagnostic choices and treatment strategies.
Clinical Laboratory Services
Clinical Laboratory Science, also called Medical Technology provides laboratory information and services needed for the diagnosis and treatment of disease. Clinical laboratory scientists perform a variety of laboratory tests, ensure the quality of the test results, explain the significance of laboratory tests, evaluate new methods and study the effectiveness of laboratory tests..
Because we only treat children, phlebotomists at Children's Hospital Oakland's Clinical Laboratory are experts at drawing blood and collecting samples from infants and children using microtechniques to minimize the amount of blood drawn.
The Clinical Laboratory provides a full range of inpatient and outpatient laboratory testing services:
- Specialized Pediatric Phlebotomy Services
- Chemistry and Toxicology
- Hematology
- Urinalysis
- Coagulation
- Microbiology
- Immunology
- Transfusion Services
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- Point of Care Testing
- Molecular Diagnostics
- Molecular Genetics
- Hemoglobinopathy
- Bone marrow testing—HLA/Immunogenetics Services
- Specialized Send-out Testing
- Clinical Pathology Consultation
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The Department of Pathology and Laboratory Medicine is fully accredited by the College of American Pathologists (CAP), and licensed by the State of California, the Clinical Laboratory Improvement Act (CLIA), and the Food & Drug Administration (FDA) for transfusion services.
Esoteric Specialty Laboratory Services
Esoteric Specialty Laboratories
The Department provides specialized testing through the following laboratories:
Hemoglobinopathy Laboratory Services
Our full-service Hemoglobinopathy Analysis Lab is one of the only fully-equipped facilities in the state of California and functions as a state reference laboratory for specialized testing
Testing Performed in the Hemoglobinopathy Reference Lab:
(www.erythrosite.com)
Routine Tests:
- Cellulose Acetate Electrophoresis
- Citrate Agar Electrophoresis
- Thin Layer Isoelectric Focusing (Ief)
- Ion Exchange High Performance Liquid Chromatograpy (Hplc)
- Capillary Electrophoresis (Sebia)
- Solubility Test
- Free Erythrocyte Protoporphyrin (Fep)
- Pitted Rbc Count
- Hb A1c
Specialized Tests:
- Isopropanol Precipitation Test for Unstable Hemoglobins
- Heat Stability Test for Unstable Hemoglobins
- Brilliant Cresyl Blue (Bcb) Test for Inclusion Bodies
- Heinz Body Test (Methyl Violet)
- Stain for Howell-Jolly Bodies
- Rbc Analyses For Dense Cells, Fetal Hemoglobin (In Conjunction with Chori Rbc Lab)
- Oxygen-Dissociation Curve (In Conjunction with Chori Rbc Lab)
- Ektacytometry (In Conjunction with Chori Rbc Lab)
Molecular Tests:
- Multiplex Gap PCR for alpha thalassemia deletions (3.7, 4.2, SEA, FIL, MED, THAI, 20.5) & Hb Constant Spring.
- Allele-specific PCR (Hb Constant-Spring)
- DNA sequencing, beta globin gene
- DNA sequencing, alpha globin gene
- DNA sequencing, gamma globin gene
- DNA sequencing, delta globin gene
- Gap PCR for alpha gene triplication (anti -3.7 & anti -4.2)
- Gap PCR for HPFH 1, 2, 3, 7, and Vietnamese HPFH deletions
- Gap PCR for Hb Lepore (Hollandia, Washington- Boston, Baltimore)
- Gap PCR for anti-Lepore Hbs
- Gap PCR for 118kb Filipino beta thalassemia deletion
- Gap PCR for -619bp Indian beta thalassemia deletion
- Multiplex Gap PCR for beta thalassemia deletions: 35.8kb Black deletion, Sicilian deletion, 3.5kb Thai deletion, 1393bp Black deletion, and11.8kb Black deletion
- Allele-specific PCR for Hb S
- Allele-specific PCR for Hb E
- Multiplex Ligation-Dependent Probe Amplification (MLPA) for beta globin locus deletions
- Multiplex Ligation-Dependent Probe Amplification (MLPA) for alpha globin locus deletions
- Restriction digestion for GGamma Xmn1 polymorphism.
- Extraction of DNA by BioRobot M48
- Extraction of DNA by Qiagen (manual)
- Extraction of DNA from Amniotic Fluid
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