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Singer, Sylvia, MD

Sylvia Singer

MD

Pediatric Hematology-Oncology

Director, Hemostasis and Thrombosis

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Clinical Specialties

Cancer, tumors, sarcoma, chemotherapy, targeted therapy, brain and spinal cord tumors, pediatric oncology, hepatoblastoma, wilms tumor blood and bone marrow cancers, blood disorders, anemia, clotting disorders, sickle cell disease, hemophilia, leukemia and lymphoma, hodgkins and non-hodgkins, stem cell transplantation

Certifications

Board Certification
  • Pediatric Hematology-Oncology (American Board of Pediatrics)

Education

Medical School

Hebrew University, Jerusalem, Israel

Fellowship

Weitzman Institute of Medicine, Israel
(Research Fellow, Bone Marrow Transplant)

Fellowship

Children's Hospital & Research Center Oakland, Oakland, CA
(Pediatric Hematology Oncology)

Fellowship

Children’s Hospital Oakland Research Institute, Oakland, CA
(Research Fellow)

Residency

Hadassah University Medical Center, Isreal
(Pediatrics)

Residency

Tel Hashomer Hospital, Tel-Aviv, Israel
(Pediatrics)

Clinic Locations

My Work

About Me

Dr. Singer is a senior clinician and clinical scientist in our program. She has a strong research and clinical background in iron, thalassemia, hemostasis, oxidative injury and coagulation abnormalities. Her NHLBI K23 award focused on mechanisms and treatment of pulmonary hypertension in thalassemia in which she was one of the first to define the role of hypercoagulation, oxidative injury, and nitrix oxide depletion in pulmonary hypertension in thalassemia. She has recently been studying pulmonary hypertension and splenectomy across hemolytic diseases including spherocytosis, transfused/non-transfused thalassemia, Hb H Constant Spring, and has identified the key role of hemolysis and spleen absence in PHT. With Cooley’s Anemia Foundation research funding, she developed a clinical and research program to address the etiology of fertility disorders in iron overload and its relationship to endocrinopathy and oxidative injury. She developed a clinical model for prediction of fertility and uncovered the role of oxidative damage as a cause of ovarian dysfunction. She has developed targeted therapy to prevent and modify ovum damage. She is also now the PI for a number of trials of new agents affecting hemostasis.

Selected Research and Publications:

  1. Singer ST, Vichinsky EP, Larkin S, Olivieri N, Sweeters N, Kuypers FA; E/beta Thalassemia Study Group.Hydroxycarbamide-induced changes in E/beta-thalassemia red blood cells. Am J Hematol. 2008 Nov;83(11):842-5.
  2. Singer ST,Sweeters N, Vichinsky V, Rachmilewitz E. Darbepoetin Alfa for the treatment of anemia in Thalassemia Intermedia. Br J Haematol. 2011 Jul;154(2):281-4; 2011.
  3. Singer ST, Vichinsky EP, Gildengorin G, van Disseldorp J, Rosen M, Cedars MI. Reproductive capacity in iron overloaded women with thalassemia major. Blood. Sep 8;118(10):2878-81; 2011.
  4. Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA, Vichinsky EP. Thalassemia Clinical Research Network. Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension. Haematologica. 2013 Sep;98(9):1359-67.
  5. Thompson AA, Kim HY, Singer ST, Vichinsky E, Eile J, Yamashita R, Giardina PJ, Olivieri N, Parmar N, Trachtenberg F, Neufeld EJ, Kwiatkowski JL; Thalassemia Clinical Research Network. Pregnancy outcomes in women with thalassemia in North America and the United Kingdom. Am J Hematol. 2013 Sep;88(9):771-3.
  6. Singer ST, Kuypers F, Fineman J, Gildengorin G et al. Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy. Ann Hematol. 2014 Jul;93(7):1139-48.
  7. Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF. Fertility in transfusion-dependent thalassemia men: Effects of iron burden on the reproductive axis. Am J Hematol. 2015 Sep;90(9):E190-2.